Association between omega-3/6 fatty acids and cholelithiasis: A mendelian randomization study.

ABSTRACT:

Background

Omega-3 and omega-6 may be protective factors for cholelithiasis. However, this relationship has not yet been demonstrated clearly. Therefore, we attempted to identify these causal relationships.

Materials and methods

The omega-3/6 fatty acid discovery dataset was obtained from UK Biobank and contained 114,999 individuals. The validation set was derived from an independent genome-wide association study (GWAS) and contained 13,544 individuals. The cholelithiasis dataset was derived from FinnGen and contained 19,023 cases and 195,144 controls. The inverse variance weighting (IVW) method was used as the main method of analysis in this study. Multiple methods of analysis were also used in the repeated methods, including the MR-Egger, weighted median, MR-pleiotropic re

SUBMITTER: Sun Q 

PROVIDER: S-EPMC9537577 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature