Association between microbiological risk factors and neurodegenerative disorders: An umbrella review of systematic reviews and meta-analyses.

ABSTRACT: The role of microbiological factors in the development of neurodegenerative diseases is attracting increasing attention, while the relationship remains debated. This study aimed to comprehensively summarize and evaluate the associations between microbiological factors and the risk of neurodegenerative disorders with an umbrella review. PubMed, Embase, and the Cochrane library were used to search for papers from the earliest to March 2021 for identifying meta-analyses and systematic reviews that examined associations between microbiological factors and neurodegenerative diseases. AMSTAR2 tool was employed to evaluate the methodical quality of systematic reviews and meta-analyses. The effect size and 95% confidence interval (95% CI) were recalculated with a random effect model after the over

SUBMITTER: Wang X 

PROVIDER: S-EPMC9537612 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature