Association between fat mass and obesity-related variant and osteoarthritis risk: Integrated meta-analysis with bioinformatics.

ABSTRACT:

Objective

The association of fat mass and obesity-related (FTO) gene with osteoarthritis (OA) risk has been investigated in multiple genome-wide association studies but showed inconsistent results. Our study aimed to assess FTO expression in different OA sequencing datasets and to meta-analyze whether FTO polymorphism was associated with the risk of osteoarthritis.

Method

Gene expression profiles were obtained from ArrayExpress, Gene Expression Omnibus (GEO), and BioProject databases. Three electronic databases including PubMed and EMBASE were systematically retrieved to identify articles exploring the association between FTO polymorphisms and OA risk published before September 2022. Summary odds ratios (ORs) and corresponding 95% confidence inter

SUBMITTER: Zhao K 

PROVIDER: S-EPMC9537627 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature