Predictors of associated and multiple autoimmunity in children and adolescents with type 1 diabetes mellitus.

ABSTRACT:

Purpose

Type 1 diabetes mellitus (T1DM) is an autoimmune condition characterised by the presence of antipancreatic antibodies. The autoimmune process is also directed against other organs, most frequently against the thyroid gland, intestinal mucosa, and gastric parietal cells.

Methods

Our investigation included 121 children with T1DM with a mean age±standard deviation of 11.99±4.63 years (range, 2.0-20.0 years). We explored the frequency of associated autoimmunity; the presence of predictive factors such as current age, sex, and severity at diabetes diagnosis; T1DM duration; and family history of autoimmunity.

Results

Associated autoimmunity was present in 28.9% of T1DM patients. Children with associated autoimmunity were older at diabetes diagnosis (p=0.009) and had

SUBMITTER: Kakleas K 

PROVIDER: S-EPMC9537678 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature