Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population.

ABSTRACT:

Background

Erythrocyte invasion by P. falciparum involves functionally overlapping interactions between the parasite's ligands and the erythrocyte surface receptors. While some P. falciparum isolates necessarily engage the sialic acid (SA) moieties of the erythrocytes during the invasion, others use ligands whose binding is independent of SA for successful invasion. Deciphering the major pathway used by P. falciparum clinical isolates represent a key step toward developing an efficient blood stage malaria vaccine.

Methods

We collected a total of 156 malaria-infected samples from Ghanaian children aged 2 to 14 years and used a two-color flow cytometry-based invasion assay to assess the invasion phenotype diversity of Ghanaian P. falciparum clinical isolates. Anti-human CR1 an

SUBMITTER: Thiam LG 

PROVIDER: S-EPMC9537689 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature