GABA_A receptors as targets for anaesthetics and analgesics and promising candidates to help treat coronavirus infections: A mini-review.

ABSTRACT: GABA is a major inhibitory neurotransmitter that regulates the balance between excitatory and inhibitory circuits in the human nervous system. The GABA receptors are divided into three main subtypes, GABA_A , GABA_B , and GABA_C (also termed GABA_A rho) receptors. GABA_A receptors are pentameric ligand-gated ion channels widely expressed throughout the central and peripheral nervous system. The activation of GABA_A receptors results in opening of an anion-selective channel that mainly gates chloride ions and allows them to flow into the neuron, causing hyperpolarization of the cell membrane that dampens neural excitability. This makes GABA_A receptors critical anaesthetic and analgesic targets for existing as well as for

SUBMITTER: Luo Y 

PROVIDER: S-EPMC9538268 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature