Protein-imprinted particles for coronavirus capture from solution.

ABSTRACT: Molecular imprinting is a promising strategy to selectively adsorb viruses, but it requires discerning and validating epitopes that serve as effective imprinting templates. In this work, glycoprotein-imprinted particles were synthesized for coronavirus capture. Adsorption was maximized at pH 6 (the glycoprotein isoelectric point) where the glycoprotein-imprinted particles outperformed non-imprinted particles, adsorbing 4.96 × 10⁶  ± 3.33 × 10³ versus 3.54 × 10⁶  ± 1.39 × 10⁶ median tissue culture infectious dose/mg of the target coronavirus, human coronavirus - organ culture 43, within the first 30 min (p = 0.012). During competitive adsorption, with pH adjustment (pH 6), the glycoprotein-imprinted particles adsorbed more target virus than non-ta

SUBMITTER: Senehi NL 

PROVIDER: S-EPMC9538460 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature