The predictive value of total-body PET/CT in non-small cell lung cancer for the PD-L1 high expression.

ABSTRACT:

Purpose

Total-body positron emission tomography/computed tomography (PET/CT) provides faster scanning speed, higher image quality, and lower injected dose. To compensate for the shortcomings of the maximum standard uptake value (SUVmax), we aimed to normalize the values of PET parameters using liver and blood pool SUV (SUR-L and SUR-BP) to predict programmed cell death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) patients.

Materials and methods

A total of 138 (104 adenocarcinoma and 34 squamous cell carcinoma) primary diagnosed NSCLC patients who underwent ¹⁸F-FDG-PET/CT imaging were analyzed retrospectively. Immunohistochemistry (IHC) analysis was performed for PD-L1 expression on tumor cells and tumor-infiltrating immune cells with 22C3 anti

SUBMITTER: Hu B 

PROVIDER: S-EPMC9538674 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature