The impact of maternal SARS-CoV-2 vaccination and first trimester infection on feto-maternal immune responses.

ABSTRACT:

Problem

COVID-19 infection during pregnancy increases maternal and fetal morbidity and mortality. Infection in the second or third trimester leads to changes in the decidual leukocyte populations. However, it is not known whether COVID-19 infection in the first trimester or COVID-19 vaccination during pregnancy alters the decidual immune environment.

Method of study

We examined decidual biopsies obtained at delivery from women who had COVID-19 in the first trimester (n = 8), were fully vaccinated against COVID-19 during pregnancy (n = 17), or were neither infected nor vaccinated during pregnancy (n = 9). Decidual macrophages, NK cells, and T cells were quantified by immunofluorescence. Decidual IL-6, IL-10, and IP-10 were quantified by ELISA.

Results

There were no dif

SUBMITTER: Juttukonda LJ 

PROVIDER: S-EPMC9538740 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature