Project description:A pivotal role of astrocytes in the pathophysiology of CNS disorders during the SARS-CoV-2 infection of brain has been proposed. Thus, the study was performed to reveal astrocyte response to infection caused by either Omicron or Delta variant.
Project description:hACE2 transgenic mice were infected with the original SARS-CoV-2 strain (B.1) and the Beta (B.1.351) variant. Lung and spleen samples were collected 1 day post infection (DPI), 3 DPI and 5 DPI, and mRNA was sequenced.