COVID-19 vaccine humoral response in frequent platelet donors with plateletpheresis-associated lymphopenia.

ABSTRACT:

Background

Plateletpheresis involves platelet separation and collection from whole blood while other blood cells are returned to the donor. Because platelets are replaced faster than red blood cells, as many as 24 donations can be done annually. However, some frequent apheresis platelet donors (>20 donations annually) display severe plateletpheresis-associated lymphopenia; in particular, CD4⁺ T but not B cell numbers are decreased. COVID-19 vaccination thereby provides a model to assess whether lymphopenic platelet donors present compromised humoral immune responses.

Study design and methods

We assessed vaccine responses following 2 doses of COVID-19 vaccination in a cohort of 43 plateletpheresis donors with a range of pre-vaccination CD4⁺ T cell counts

SUBMITTER: Laumaea AE 

PROVIDER: S-EPMC9539235 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature