Synchronous firing of dorsal horn neurons at the origin of dorsal root reflexes in naive and paw-inflamed mice.

ABSTRACT: Spinal interneurons located in the dorsal horn induce primary afferent depolarization (PAD) controlling the excitability of the afferent's terminals. Following inflammation, PAD may reach firing threshold contributing to maintain inflammation and pain. Our aim was to study the collective behavior of dorsal horn neurons, its relation to backfiring of primary afferents and the effects of a peripheral inflammation in this system. Experiments were performed on slices of spinal cord obtained from naïve adult mice or mice that had suffered an inflammatory pretreatment. Simultaneous recordings from groups of dorsal horn neurons and primary afferents were obtained and machine-learning methodology was used to analyze effective connectivity between them. Dorsal horn recordings showed grouping of spo

SUBMITTER: Lucas-Romero J 

PROVIDER: S-EPMC9539274 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature