Factors influencing the immune response over 15 months after SARS-CoV-2 infection: A longitudinal population-wide study in the Faroe Islands.

ABSTRACT:

Background

The durability of SARS-CoV-2 antibody response and the resulting immunity to COVID-19 is unclear.

Objectives

To investigate long-term humoral immunity to SARS-CoV-2.

Methods

In this nationwide, longitudinal study, we determined antibody response in 411 patients aged 0-93 years from two waves of infections (March to December 2020) contributing 1063 blood samples. Each individual had blood drawn on 4-5 occasions 1-15 months after disease onset. We measured total anti-SARS-CoV-2 receptor-binding domain (RBD) antibody using a qualitative RBD sandwich ELISA, IgM, IgG and IgA levels using an quantitative in-house ELISA-based assay  and neutralizing antibodies (NAbs) using an in-house ELISA-based pseudoneutralizing assay. IgG subclasses were analyzed in a subset o

SUBMITTER: Petersen MS 

PROVIDER: S-EPMC9539344 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature