Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy.

ABSTRACT:

Objectives

Recent studies suggested that the expansion of long-standing multiple sclerosis (MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation and microglial activation. We investigated the potential association between plexus volume and subsequent lesion expansion in patients with relapsing-remitting MS.

Methods

Pre- and post-gadolinium 3D-T1, 3D FLAIR and diffusion tensor images were acquired from 49 patients. Choroid plexus (CP) volume (normalised by Total Intracranial Volume, TIV) and lesion activity were analysed between baseline and 48 months. In addition, plexus volume was measured in 40 healthy controls of similar age and gender.

Results

Baseline CP/TIV ratio was significantly larger in RRMS patients compared to normal contr

SUBMITTER: Klistorner S 

PROVIDER: S-EPMC9539382 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature