Subtle vascular and astrocytic changes in the brain of coronavirus disease 2019 (COVID-19) patients.

ABSTRACT:

Background and purpose

In the central nervous system, a multitude of changes have been described associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, such as microglial activation, perivascular lymphocyte cuffing, hypoxic-ischaemic changes, microthrombosis, infarcts or haemorrhages. It was sought here to assess the vascular basement membranes (vBMs) and surrounding perivascular astrocytes for any morphological changes in acute respiratory syndrome (coronavirus disease 2019, COVID-19) patients.

Methods

The light microscopy morphology of the vBMs and perivascular astrocytes from brains of 14 patients with confirmed SARS-CoV-2 infection was analysed and compared to four control patients utilizing fluorescent immunohistochemistry for collagen I

SUBMITTER: Rosu GC 

PROVIDER: S-EPMC9539405 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature