Diagnostic accuracy and prognostic significance of Glypican-3 in hepatocellular carcinoma: A systematic review and meta-analysis.

ABSTRACT:

Purpose

Glypican-3 (GPC-3) expression is abnormal in the occurrence and development of hepatocellular carcinoma (HCC). To explore whether GPC-3 has diagnostic accuracy and prognostic significance of HCC, we did a systematic review and meta-analysis.

Method

PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure were searched with keywords "GPC-3" and "HCC" and their MeSH terms from inception to July 2022. We applied the hierarchical summary receiver operating characteristic model and evaluated the diagnostic value of GPC-3 alone and combination, and the correlation between high and low GPC-3 expression on clinicopathological features and survival data in prognosis.

Results

Forty-one original publications with 6,305 participants were included, wit

SUBMITTER: Jiang D 

PROVIDER: S-EPMC9539414 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature