Association of HLA-DPA1 polymorphism with prolonged mechanical ventilation in patients undergoing liver transplantation.

ABSTRACT:

Background

Prolonged mechanical ventilation (PMV) is a common complication after liver transplantation surgery. However, owing to the clinical and economic benefits of early extubation, many efforts have been used to assess the clinical predictors for PMV. The aim of our study was to explore the impact of perioperative risk factors, including candidate gene polymorphisms, for PMV in patients undergoing liver transplantation.

Methods

One hundred forty patients who underwent liver transplantation surgery were enrolled. The duration of mechanical ventilation after surgery was examined, along with the length of intensive care unit and hospital stay, and 30-day mortality. Patient-related clinical factors and single nucleotide polymorphisms of candidate genes were assessed with re

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC9539425 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature