Volumetric parameters from [¹⁸ F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.

ABSTRACT: A positive fluorine-18 labelled 2-deoxy-2-fluoroglucose ([¹⁸ F]FDG) positron emission tomography/computed tomography (PET/CT) has been associated with more aggressive disease and less differentiated neuroendocrine neoplasms (NEN). Although a high maximum standardized uptake value (SUV_max ) predicts poor outcome in NEN, volumetric parameters from [¹⁸ F]FDG PET have not been evaluated for prognostication in a pure high-grade gastroenteropancreatic (GEP) NEN cohort. In this retrospective observational study, we evaluated the volumetric PET parameters total metabolic tumour volume (tMTV) and total total lesion glycolysis (tTLG) for independent prognostication of overall survival (OS). High-grade GEP NEN patients with [¹⁸ F]FDG PET/CT examination and

SUBMITTER: Langen Stokmo H 

PROVIDER: S-EPMC9539477 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature