Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma.

ABSTRACT:

Background

To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC).

Methods

One hundred and forty-seven patients were included. The association between local treatment and OS was examined with propensity score matching (PSM) method.

Results

In entire cohort, the median OS was significantly longer in patients with local treatment of metastases plus chemotherapy compared to those with chemotherapy alone (71.7 vs. 16.2 months; p < 0.001). In PSM cohort, similar OS benefit of patients with local treatment was observed (55.6 vs. 17.6 months; p = 0.011). The survival benefit of local treatment remained regardless of the number of metastatic lesions and metastatic sites. Patients received

SUBMITTER: Liao W 

PROVIDER: S-EPMC9539515 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature