Deep structural insights into RNA-binding disordered protein regions.

ABSTRACT: Recent efforts to identify RNA binding proteins in various organisms and cellular contexts have yielded a large collection of proteins that are capable of RNA binding in the absence of conventional RNA recognition domains. Many of the recently identified RNA interaction motifs fall into intrinsically disordered protein regions (IDRs). While the recognition mode and specificity of globular RNA binding elements have been thoroughly investigated and described, much less is known about the way IDRs can recognize their RNA partners. Our aim was to summarize the current state of structural knowledge on the RNA binding modes of disordered protein regions and to propose a classification system based on their sequential and structural properties. Through a detailed structural analysis of the comple

SUBMITTER: Zeke A 

PROVIDER: S-EPMC9539567 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature