Confirmed disability progression as a marker of permanent disability in multiple sclerosis.

ABSTRACT:

Background and purpose

The prevention of disability over the long term is the main treatment goal in multiple sclerosis (MS); however, randomized clinical trials evaluate only short-term treatment effects on disability. This study aimed to define criteria for 6-month confirmed disability progression events of MS with a high probability of resulting in sustained long-term disability worsening.

Methods

In total, 14,802 6-month confirmed disability progression events were identified in 8741 patients from the global MSBase registry. For each 6-month confirmed progression event (13,321 in the development and 1481 in the validation cohort), a sustained progression score was calculated based on the demographic and clinical characteristics at the time of progression that were predic

SUBMITTER: Sharmin S 

PROVIDER: S-EPMC9539581 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature