Irritable bowel syndrome patients who are not likely to respond to fecal microbiota transplantation.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) interventions have recently been advocated to not succeed in every irritable bowel syndrome (IBS) patient, since the outcome of FMT varies with the IBS subset. This study investigated the factors potentially affecting FMT response using the same patient cohort used in our previous study.

Methods

This study included 109 patients who received allogenic FMT. Patients completed five questionnaires that assessed their symptoms and quality of life at baseline and at 2 weeks, 1 month, and 3 months after FMT. Patients also provided fecal samples at baseline and 1 month after FMT. The fecal bacterial profile and dysbiosis index (DI) were determined using 16S rRNA gene PCR DNA amplification covering variable genes V3-V9. Response to FM

SUBMITTER: El-Salhy M 

PROVIDER: S-EPMC9539588 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature