Circulating miRNAs in girls with abdominal obesity: miR-221-3p as a biomarker of response to weight loss interventions.

ABSTRACT:

Background

Recent studies have associated several microRNAs (miRNAs) with childhood obesity and energy homeostasis, suggesting that an individual miRNA profile could be used as an early predictor to estimate the response to weight loss interventions in the design of precision nutrition.

Objective

To investigate associations between the expression of circulating adiposity-related miRNAs and the response to a weight loss intervention.

Methods

A total of 51 Spanish girls (age 7-16 years) with abdominal obesity underwent 8 weeks of a multidisciplinary intervention for weight loss. Participants were stratified into two groups in accordance with changes in body mass index (BMI) standard deviation score: low-responders (LR) and high-responders (HR). The expression of 39 circ

SUBMITTER: Ojeda-Rodriguez A 

PROVIDER: S-EPMC9539627 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature