Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance.

ABSTRACT: Even though studies have shown that prenatal maternal stress is associated with increased reactivity of the HPA axis, the association between prenatal maternal stress and fetal glucocorticoid exposure is complex and most likely dependent on unidentified and poorly understood variables including nature and timing of prenatal insults. The precise mechanisms in which prenatal maternal stress influence neuroendocrine signaling between the maternal-placental-fetal interface are still unclear. The aim of this review article is to bring comprehensive basic concepts about prenatal maternal stress and mechanisms of transmission of maternal stress to the fetus. This review covers recent studies showing associations between maternal stress and alterations in offspring aggressive behavior, as well as

SUBMITTER: Mbiydzenyuy NE 

PROVIDER: S-EPMC9539686 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature