Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors.

ABSTRACT:

Importance

Differences in cerebrospinal fluid (CSF) tau Alzheimer dementia (AD) biomarkers by self-identified race have been observed in prior studies. More recently, plasma biomarkers have been gaining recognition, but whether they exhibit similar differences is unclear. Furthermore, the underlying explanation for these differences in AD biomarkers is still unexplored.

Objectives

To investigate differences in plasma biomarkers by race and genetic ancestry and explore potential underlying explanations for these differences.

Design, setting, and participants

This cross-sectional study used participant data from the Brain, Stress, Hypertension, and Aging Research Program (B-SHARP), an observational study conducted in the greater Atlanta metropolitan area. Participants w

SUBMITTER: Hajjar I 

PROVIDER: S-EPMC9539715 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature