Microelectrode Arrays for Simultaneous Electrophysiology and Advanced Optical Microscopy.

ABSTRACT: Advanced optical imaging techniques address important biological questions in neuroscience, where structures such as synapses are below the resolution limit of a conventional microscope. At the same time, microelectrode arrays (MEAs) are indispensable in understanding the language of neurons. Here, the authors show transparent MEAs capable of recording action potentials from neurons and compatible with advanced microscopy. The electrodes are made of the conducting polymer poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) and are patterned by optical lithography, ensuring scalable fabrication with good control over device parameters. A thickness of 380 nm ensures low enough impedance and >75% transparency throughout the visible part of the spectrum making them su

SUBMITTER: Middya S 

PROVIDER: S-EPMC9539726 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature