Pooled Analysis of Meningioma Risk Following Treatment for Childhood Cancer.

ABSTRACT:

Importance

Meningioma is the most common subsequent neoplasm following cranial irradiation among survivors of childhood cancer, but there are still uncertainties regarding the magnitude of the radiation dose-response association, potential modifiers of radiation risks, and the role of chemotherapy.

Objective

To evaluate meningioma risk in survivors of childhood cancer following radiotherapy and chemotherapy and identify possible modifying factors of radiation-associated risk.

Design, setting, and participants

This international case-control study pooled data from 4 nested case-control studies of survivors of childhood cancer diagnosed between 1942 and 2000, followed through 2016. Cases were defined as participants diagnosed with a subsequent meningioma. Controls were

SUBMITTER: Withrow DR 

PROVIDER: S-EPMC9539736 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature