Protective effects of chlorogenic acid against ionizing radiation-induced testicular toxicity.

ABSTRACT:

Background

Testicular tissues could damage by ionizing radiation (IR) during the treatment of pelvic cancers. The aim of this study was to investigate both the protective and therapeutic effects of chlorogenic acid (CGA) on IR-induced mouse testis tissue damage.

Methods

In this experimental study, 70 mice were divided into 3 groups, including group 1 (normal saline), group 2 (IR + normal saline), and group 3 (IR + 5, 10, 20, 40, and 80 mg/kg) CGA via I.P injection. Animals in groups 2 and 3 received a dose of 2.0 Gy total-body irradiation in a single fraction. At two determined time points (16 h and 35 days after exposure), the testis and caudal part of both epididymis were isolated and underwent subsequent analyses.

Results

The results showed that irradiation

SUBMITTER: Abedpour N 

PROVIDER: S-EPMC9539785 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature