IgE receptor responsiveness of basophils in chronic inducible urticaria.

ABSTRACT:

Introduction

Chronic inducible urticaria (CIndU) is a subgroup of chronic urticaria induced by a specific stimulus. We evaluated basophil characteristics in patients with CIndU and compared with those in patients with chronic spontaneous urticaria (CSU) and healthy controls (HCs).

Methods

Blood was collected from patients, and a basophil activation test (BAT) was performed. Basophil responsiveness and surface marker expression in patients with CIndU were compared with those in patients with CSU and HCs. For some patients with CIndU, blood was collected before and after wheals were induced. In these cases, we compared the responsiveness of basophils before and after the appearance of wheals.

Result

HCs (n=23) and patients with CIndU (n=24) or CSU (n=38) were enrolled i

SUBMITTER: Mizuno M 

PROVIDER: S-EPMC9539802 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature