Protective role of host complement system in Aspergillus fumigatus infection.

ABSTRACT: Invasive aspergillosis (IA) is a life-threatening fungal infection for immunocompromised hosts. It is, therefore, necessary to understand the immune pathways that control this infection. Although the primary infection site is the lungs, aspergillosis can disseminate to other organs through unknown mechanisms. Herein we have examined the in vivo role of various complement pathways as well as the complement receptors C3aR and C5aR1 during experimental systemic infection by Aspergillus fumigatus, the main species responsible for IA. We show that C3 knockout (C3^-/-) mice are highly susceptible to systemic infection of A. fumigatus. Intriguingly, C4^-/- and factor B (FB)^-/- mice showed susceptibility similar to the wild-type mice, suggesting

SUBMITTER: Shende R 

PROVIDER: S-EPMC9539816 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature