Gut microbiota profiling revealed the regulating effects of salidroside on iron metabolism in diabetic mice.

ABSTRACT:

Background

Diabetes is a common metabolic disease that is associated with gut microbiota dysbiosis and iron metabolism. Salidroside (SAL) is the main ingredient of the traditional Chinese herb Rhodiola, previous studies have shown that SAL could reshape the gut microbiota and limit iron accumulation. Therefore, it is possible that SAL can act as an alternative therapy for diabetes, and its underlying mechanism is worth exploring.

Methods

SAL was used to treat diabetic db/db mice. Serum glucose and iron levels and the histopathology of myocardial fibres were evaluated. The gut microbiota composition was determined by 16S rRNA Illumina sequencing technology.

Results

Treatment with SAL significantly reduced blood glucose and ameliorated diabetic cardiomyopathy in diabeti

SUBMITTER: Shi J 

PROVIDER: S-EPMC9539846 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature