Osteosarcoma subtypes based on platelet-related genes and tumor microenvironment characteristics.

ABSTRACT:

Background

Osteosarcoma is a common metastatic tumor in children and adolescents. Because of its easy metastasis, patients often show a poor prognosis. Recently, researchers have found that platelets are closely related to metastasis of a variety of malignant tumors, but the role of platelets related characteristics in osteosarcoma is still unknown. The purpose of this study is to explore the characteristics of platelet-related subtypes and cell infiltration in tumor microenvironment.

Methods

We collected osteosarcoma cohorts from TCGA and GEO databases, and explored the molecular subtypes mediated by platelet-related genes and the related TME cell infiltration according to the expression of platelet-related genes in osteosarcoma. In addition, we also explored the differenti

SUBMITTER: Shu Y 

PROVIDER: S-EPMC9539847 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature