Methyltransferases: Functions and Applications.

ABSTRACT: In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.

SUBMITTER: Abdelraheem E 

PROVIDER: S-EPMC9539859 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature