Association between age and the presence and mortality of breast cancer synchronous brain metastases in the United States: A neglected SEER analysis.

ABSTRACT:

Background

The extent of the relationship between age and the presence of breast cancer synchronous brain metastases (BCSBMs) and mortality has not yet been well-identified or sufficiently quantified. We aimed to examine the association of age with the presence of BCSBMs and all-cause and cancer-specific mortality outcomes using the SEER database.

Methods

Age-associated risk of the presence and survival of BCSBMs were evaluated on a continuous scale (restricted cubic spline, RCS) with logistic or Cox regression models. The main endpoints were the presence of BCSBMs and all-cause mortality or cancer-specific mortality. Cox proportional hazards regression and competing risk models were used in survival analysis.

Results

Among 374,132 adult breast cancer patients, 1,441

SUBMITTER: Che W 

PROVIDER: S-EPMC9539918 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature