Evaluation of clotrimazole prophylaxis on tacrolimus trough concentrations in kidney transplant recipients.

ABSTRACT:

Background

Clotrimazole troches are used as prophylaxis against oropharyngeal candidiasis post-transplant and have limited systemic absorption. Following several occurrences of tacrolimus concentration fluctuations after clotrimazole discontinuation, its use as prophylaxis was discontinued post-kidney transplant.

Methods

We conducted a retrospective cohort study to evaluate the effect of clotrimazole prophylaxis on tacrolimus trough concentrations post-kidney transplant. The study included adult patients who received a kidney transplant at Cleveland Clinic Main Campus from August 1, 2019 to July 1, 2020 and were maintained on per-protocol, standard-dose tacrolimus through 90 days post-transplant. Patients were excluded if they received cyclosporine, systemic antifungals, str

SUBMITTER: Wings E 

PROVIDER: S-EPMC9540224 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature