Linoleic Acid-Rich Oil Alters Circulating Cardiolipin Species and Fatty Acid Composition in Adults: A Randomized Controlled Trial.

ABSTRACT:

Scope

Higher circulating linoleic acid (LA) and muscle-derived tetralinoleoyl-cardiolipin (LA₄ CL) are each associated with decreased cardiometabolic disease risk. Mitochondrial dysfunction occurs with low LA₄ CL. Whether LA-rich oil fortification can increase LA₄ CL in humans is unknown. The aims of this study are to determine whether dietary fortification with LA-rich oil for 2 weeks increases: 1) LA in plasma, erythrocytes, and peripheral blood mononuclear cells (PBMC); and 2) LA₄ CL in PBMC in adults.

Methods and results

In this randomized controlled trial, adults are instructed to consume one cookie per day delivering 10 g grapeseed (LA-cookie, N = 42) or high oleate (OA) safflower (OA-cookie, N = 42) oil. In the LA-cookie gro

SUBMITTER: Cole RM 

PROVIDER: S-EPMC9540417 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature