Long-term effects of lower versus higher oxygenation levels in adult ICU patients-A systematic review.

ABSTRACT:

Background

Oxygen therapy is a common treatment in the intensive care unit (ICU) with both potentially desirable and undesirable long-term effects. This systematic review aimed to assess the long-term outcomes of lower versus higher oxygenation strategies in adult ICU survivors.

Methods

We included randomised clinical trials (RCTs) comparing lower versus higher oxygen supplementation or oxygenation strategies in adults admitted to the ICU. We searched major electronic databases and trial registers. We included all non-mortality long-term outcomes. Prespecified co-primary outcomes were the long-term cognitive function measures, the overall score of any valid health-related quality of life (HRQoL) evaluation, standardised 6-min walk test, and lung diffusion capacity. The proto

SUBMITTER: Crescioli E 

PROVIDER: S-EPMC9540426 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature