Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts.

ABSTRACT:

Background and objective

Severe asthma (SA) is a heterogeneous disease. Transcriptomic analysis contributes to the understanding of pathogenesis necessary for developing new therapies. We sought to identify and validate mechanistic pathways of SA across two independent cohorts.

Methods

Transcriptomic profiles from U-BIOPRED and Australian NOVocastrian Asthma cohorts were examined and grouped into SA, mild/moderate asthma (MMA) and healthy controls (HCs). Differentially expressed genes (DEGs), canonical pathways and gene sets were identified as central to SA mechanisms if they were significant across both cohorts in either endobronchial biopsies or induced sputum.

Results

Thirty-six DEGs and four pathways were shared across cohorts linking to tissue remodelling/repair

SUBMITTER: Sanchez-Ovando S 

PROVIDER: S-EPMC9540453 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature