Recyclable Mn(I) Catalysts for Base-Free Asymmetric Hydrogenation: Mechanistic, DFT and Catalytic Studies.

ABSTRACT: We report here a mechanistic, DFT and catalytic study on a series of Mn(I) complexes 1, 2(a-d), 3, 4. The studies apprehended the requirements for Mn(I) complexes to be active in both asymmetric direct (AH) and transfer hydrogenations (ATH). The investigations disclosed 6 vital factors accelerating the formation of a resting species, which plays a significant role in lowering the activities of the Mn(I) complex 1 in ATH and AH, respectively. In addition, we also report here a base free Mn(I) catalyzed ATH of aryl alkyl ketones with high enantioselectivity (up to 98 % ee) and improved activity. More significantly, a novel and simple single-step process for recycling the resting species from the catalytic leftover has been discovered. Notably, the studies provide evidence for the existence o

SUBMITTER: Jayaprakash H 

PROVIDER: S-EPMC9540457 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature