Divide and Conquer: A Tailored Solid-state NMR Approach to Study Large Membrane Protein Complexes.
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ABSTRACT:
SUBMITTER: Xiang S
PROVIDER: S-EPMC9540533 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
Divide and Conquer: A Tailored Solid-state NMR Approach to Study Large Membrane Protein Complexes.
Xiang ShengQi S Pinto Cecilia C Baldus Marc M
Angewandte Chemie (International ed. in English) 20220707 33
Membrane proteins are known to exert many essential biological functions by forming complexes in cell membranes. An example refers to the β-barrel assembly machinery (BAM), a 200 kDa pentameric complex containing BAM proteins A-E that catalyzes the essential process of protein insertion into the outer membrane of gram-negative bacteria. While progress has been made in capturing three-dimensional structural snapshots of the BAM complex, the role of the lipoprotein BamC in the complex assembly in ...[more]
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