Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity.

ABSTRACT: Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy balance regulation. A model of intracerebroventricular administration of neuraminidase (NA, which is present in various pathogens such as influenza virus) was used to induce acute neuroinflammation. Evidences of primed microglia were observed 3 months after NA injection, namely (1) a heightened response of microglia located in the hypothalamic arcuate nucleus after an in vivo inflammatory challenge (high fat diet [HFD] feeding for 10 days), and (2) an enhanced response of microglia isolated from NA-treated mice and challenged in vitro to LPS. On the other hand, the conse

SUBMITTER: Fernandez-Arjona MDM 

PROVIDER: S-EPMC9540536 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature