Anti-inflammatory protective effect of ADAMTS-13 in murine arthritis models.

ABSTRACT:

Background

Patients with rheumatoid arthritis (RA) have frequent thrombotic events with endothelial dysfunction. Von Willebrand factor (VWF) has been shown to bind neutrophil extracellular traps (NETs) and NETs are part of RA etiology.

Objectives

This study aims to elucidate whether this prothrombotic status exacerbates inflammation in arthritis. Here we focus on the involvement of A Disintegrin And Metalloprotease with ThromboSpondin type 1 motif, member 13 (ADAMTS-13), an enzyme cleaving VWF and its effect on NET deposition and RA development.

Methods

We evaluated the influence of the Adamts13 gene and recombinant human ADAMTS-13 (rhADAMTS-13) on arthritis in the mouse models of collagen-induced arthritis (CIA). We also assessed VWF and NETs in synovial tissue.

R

SUBMITTER: Fukui S 

PROVIDER: S-EPMC9540605 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature