Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry.

ABSTRACT:

Background

Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic content, and these abnormalities may be due to either a primary jejunal dysfunction or a reflex distortion. The objective of the present study was to determine the effect of colonic distension on small bowel postprandial motility using high-resolution manometry.

Methods

Single center, controlled, parallel, randomized, single blind study in healthy subjects testing the effect of colonic filling vs sham infusion on the responses to a meal in 16 healthy subjects. Nutrients were continuously infused in the proximal jejunum (2 Kcal/min) during the 2-h study period to induce a steady-state postprandial motor pattern. Jejunal motility was measured by water-perfused, high-resoluti

SUBMITTER: Alcala-Gonzalez LG 

PROVIDER: S-EPMC9540628 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature