Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.

ABSTRACT: Survival in many animals requires the ability to associate certain cues with danger and others with safety. In a Drosophila melanogaster aversive olfactory conditioning paradigm, flies are exposed to two odours, one presented coincidentally with electrical shocks, and a second presented 45 s after shock cessation. When flies are later given a choice between these two odours, they avoid the shock-paired odour and prefer the unpaired odour. While many studies have examined how flies learn to avoid the shock-paired odour through formation of odour-fear associations, here we demonstrate that conditioning also causes flies to actively approach the second odour. In contrast to fear memories, which are longer lasting and requires activity of D1-like dopamine receptors only in the mushroom bodies,

SUBMITTER: Naganos S 

PROVIDER: S-EPMC9540629 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature