Bet v 1 triggers antiviral-type immune signalling in birch-pollen-allergic individuals.

ABSTRACT:

Background

In allergic patients, clinical symptoms caused by pollen remind of symptoms triggered by viral respiratory infections, which are also the main cause of asthmatic exacerbations. In patients sensitized to birch pollen, Bet v 1 is the major symptom-causing allergen. Immune mechanisms driving Bet v 1-related responses of human blood cells have not been fully characterized.

Objective

To characterize the immune response to Bet v 1 in peripheral blood in patients allergic to birch pollen.

Methods

The peripheral blood mononuclear cells of birch-allergic (n = 24) and non-allergic (n = 47) adolescents were stimulated ex-vivo followed by transcriptomic profiling. Systems-biology approaches were employed to decipher disease-relevant gene networks and deconvolution of a

SUBMITTER: Wisgrill L 

PROVIDER: S-EPMC9540660 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature