Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization.

ABSTRACT:

Background

Polygenic risk scores (PRS), which offer information about genomic risk for common diseases, have been proposed for clinical implementation. The ways in which PRS information may influence a patient's health trajectory depend on how both the patient and their primary care provider (PCP) interpret and act on PRS information. We aimed to probe patient and PCP responses to PRS clinical reporting choices METHODS: Qualitative semi-structured interviews of both patients (N=25) and PCPs (N=21) exploring responses to mock PRS clinical reports of two different designs: binary and continuous representations of PRS.

Results

Many patients did not understand the numbers representing risk, with high numeracy patients being the exception. However, all the patients still understo

SUBMITTER: Lewis ACF 

PROVIDER: S-EPMC9540716 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature