The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01_E vaccination and seasonal malaria chemoprevention versus either intervention given alone.

ABSTRACT:

Background

A recent trial of 5920 children in Burkina Faso and Mali showed that the combination of seasonal vaccination with the RTS,S/AS01_E malaria vaccine (primary series and two seasonal boosters) and seasonal malaria chemoprevention (four monthly cycles per year) was markedly more effective than either intervention given alone in preventing clinical malaria, severe malaria, and deaths from malaria.

Methods

In order to help optimise the timing of these two interventions, trial data were reanalysed to estimate the duration of protection against clinical malaria provided by RTS,S/AS01_E when deployed seasonally, by comparing the group who received the combination of SMC and RTS,S/AS01_E with the group who received SMC alone. The duration of pr

SUBMITTER: Cairns M 

PROVIDER: S-EPMC9540742 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature