BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index.

ABSTRACT:

Background

Obesity is a heritable complex phenotype that can increase the risk of age-related outcomes. Biological age can be estimated from DNA methylation (DNAm) using various "epigenetic clocks." Previous work suggests individuals with elevated weight also display accelerated aging, but results vary by epigenetic clock and population. Here, we utilize the new epigenetic clock GrimAge, which closely correlates with mortality.

Objectives

We aimed to assess the cross-sectional association of body mass index (BMI) with age acceleration in twins to limit confounding by genetics and shared environment.

Methods and results

Participants were from the Finnish Twin Cohort (FTC; n = 1424), including monozygotic (MZ) and dizygotic (DZ) twin pairs, and DNAm was measured using t

SUBMITTER: Lundgren S 

PROVIDER: S-EPMC9540898 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature