Detecting protein complexes with multiple properties by an adaptive harmony search algorithm.

ABSTRACT:

Background

Accurate identification of protein complexes in protein-protein interaction (PPI) networks is crucial for understanding the principles of cellular organization. Most computational methods ignore the fact that proteins in a protein complex have a functional similarity and are co-localized and co-expressed at the same place and time, respectively. Meanwhile, the parameters of the current methods are specified by users, so these methods cannot effectively deal with different input PPI networks.

Result

To address these issues, this study proposes a new method called MP-AHSA to detect protein complexes with Multiple Properties (MP), and an Adaptation Harmony Search Algorithm is developed to optimize the parameters of the MP algorithm. First, a weighted PPI network is c

SUBMITTER: Wang R 

PROVIDER: S-EPMC9541083 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature