Division of the role and physiological impact of multiple lysophosphatidic acid acyltransferase paralogs.

ABSTRACT:

Background

Lysophosphatidic acid acyltransferase (LPAAT) is a phospholipid biosynthesis enzyme that introduces a particular set of fatty acids at the sn-2 position of phospholipids. Many bacteria have multiple LPAAT paralogs, and these enzymes are considered to have different fatty acid selectivities and to produce diverse phospholipids with distinct fatty acid compositions. This feature is advantageous for controlling the physicochemical properties of lipid membranes to maintain membrane integrity in response to the environment. However, it remains unclear how LPAAT paralogs are functionally differentiated and biologically significant.

Results

To better understand the division of roles of the LPAAT paralogs, we analyzed the functions of two LPAAT paralogs, PlsC4 and PlsC5,

SUBMITTER: Ogawa T 

PROVIDER: S-EPMC9541089 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature